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. 2024 Feb 5;2024(2):CD015219. doi: 10.1002/14651858.CD015219.pub2

Shinkai 2021.

Study characteristics
Methods Single‐blinded RCT
Participants People with confirmed COVID‐19 (mild/moderate) admitted to 39 centres in Japan
Interventions Favipiravir, placebo
Outcomes Time to improvement in four clinical parameters:
  • temperature

  • SpO2 was defined as SpO2 remaining ≥ 96% for at least 24 hours without the use of oxygen therapy;

  • chest imaging was defined as improvement in chest imaging findings taken at least 24 hours after the previous image judged to be the worst;

  • recovery to SARS‐CoV‐2 negative was defined as two consecutive negative results on qualitative tests by nucleic acid amplification separated by at least 24 hours


and all adverse events
Notes