Fig. 8.
Principal component analysis of gene expression changes in human ALS-affected spinal cord compared to SOD1G37R mice and cultured glia. Principal component analysis of genes associated with (a) ferroptosis and (b) neurotoxic glial activation in human ALS-affected spinal cord, SOD1G37R mice, and glial cultures treated with the ferroptosis inducer RSL3. Individual values for PC1 and PC2 are projected below and to the right of the PCA plots, respectively. Symbols represent individual control and ALS cases, individual animals or independent glial cultures. Proportion of variance explained by each principal component is denoted on axes. Data are derived from z-scores of expression changes shown in Supplementary Figs. 3b, c, 7a, 9c, d and 12a