Fig. 4.

rAAV–sFKN alleviates microglia-mediated inflammation in the diabetic retinal transcriptome. A–D Heat map gene expression of all up and down regulated DEGs associated with the complement pathway, cell death and cell death regulation (A), inflammatory cytokines and chemokines (B), vascular and neuronal damage (C) and microglia activation and DR pathogenesis (D). n = 4–5 mice per treatment group across two experiments. All RNA samples were processed at the same time. All heat maps compared PBS-treated 4-wk D and 10-wk D mice to PBS-treated ND controls, and PBS-treated 4-wk D and 10-wk D mice to rAAV–sFKN-treated mice