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. 2024 Feb 5;25(1):13. doi: 10.1186/s10194-024-01720-7

Fig. 2.

Fig. 2

Migraine modifiable and non/modifiable risk factors and biological mechanisms associated with transition to chronic migraine (CM). Common pathophysiological factors between migraine and hypertension are represented in the middle. Abbreviations: BBB blood brain barrier, CGRP calcitonin gene related peptide, CSD: cortical spreading depression, ED endothelial dysfunction, HT hypertension, MMPs metalloproteinases, PAG periaqueductal grey, RAAS renin–angiotensin–aldosterone system. Created with biorender.com