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. 2001 Sep 15;2(9):800–807. doi: 10.1093/embo-reports/kve174

Table III. Phenotypes in littermate mice generated by Terc+/– × G3 Terc–/– (C57Bl6) intercrosses.

  Parents
Progeny
Generation G3 G3 G4 G4a G4 G4a G4 G4 G4
Genotype –/– +/– +/– –/– –/– +/– +/– –/– +/–
Mouse number/sex 1 (xy) 2 (xx) 3 (xy) 4 (xy) 5 (xy) 6 (xy) 7 (xy) 8 (xy) 9 (xx)
Testis normal normal severe testicular atrophy normal normal normal normal
GI tract slight villi atrophy in small intestine normal slight villi atrophy in small intestine severe atrophy in small intestine moderate atrophy in small intestine slight villi atrophy in small intestine normal normal normal
Bone marrow normal normal normal severe aplasia lymphoid cells aplasia normal normal aplasia normal
Spleen normal normal reduced size reduced size reduced size normal normal reduced size normal

aImages of the pathologies observed in these mice are shown in Figure 5.