Table III. Phenotypes in littermate mice generated by Terc+/– × G3 Terc–/– (C57Bl6) intercrosses.
Parents |
Progeny |
||||||||
---|---|---|---|---|---|---|---|---|---|
Generation | G3 | G3 | G4 | G4a | G4 | G4a | G4 | G4 | G4 |
Genotype | –/– | +/– | +/– | –/– | –/– | +/– | +/– | –/– | +/– |
Mouse number/sex | 1 (xy) | 2 (xx) | 3 (xy) | 4 (xy) | 5 (xy) | 6 (xy) | 7 (xy) | 8 (xy) | 9 (xx) |
Testis | normal | – | normal | severe testicular atrophy | normal | normal | normal | normal | – |
GI tract | slight villi atrophy in small intestine | normal | slight villi atrophy in small intestine | severe atrophy in small intestine | moderate atrophy in small intestine | slight villi atrophy in small intestine | normal | normal | normal |
Bone marrow | normal | normal | normal | severe aplasia lymphoid cells | aplasia | normal | normal | aplasia | normal |
Spleen | normal | normal | reduced size | reduced size | reduced size | normal | normal | reduced size | normal |
aImages of the pathologies observed in these mice are shown in Figure 5.