Table 2.

Performance of ARR based on different PAC detection methods for PA screening.

	Optimal cut-off	Sensitivity (95 % CI)	Specificity (95 % CI)	PPV (95 % CI)	NPV (95 % CI)
ARRPAC (CLIA, ng/dL)/DRC (CLIA, ng/dL)	30.0	0.930 (0.809–0.985)	0.918 (0.819–0.973)	0.889 (0.775–0.949)	0.949 (0.862–0.982)
ARRPAC (LC-MS/MS, ng/dL)/DRC (CLIA, ng/dL)	20.0	0.930 (0.809–0.985)	0.896 (0.798–0.942)	0.883 (0.761–0.930)	0.946 (0.855–0.981)

ARR, aldosterone-to-renin ratio; CI, confidence interval; CLIA, chemiluminescence immunoassay; DRC, direct renin concentration; LC-MS/MS, liquid chromatography with tandem mass spectrometry; NPV, negative predictive value; PAC, plasma aldosterone concentration; PPV, positive predictive value.