Table 1.
Association of colorectal cancer risk with genetically predicted expression of two miRNAs, miR-1307-5p and miR-192-3p.
| Locus | MicroRNA | Z score | P valuea | R2b | Closest risk variant | Distance (Mb)b | P value after adjusting for the risk variantc |
|---|---|---|---|---|---|---|---|
| 10q24.33 | miR-1307-5p | 3.61 | 3.08 × 10−4 | 0.20 | rs4919687 | 0.56 | 0.033 |
| 11q13.1 | miR-192-3p | −4.33 | 1.48 × 10−5 | 0.03 | rs174533 | 3.11 | 1.86 × 10−5 |
a P value derived from association analyses in TWAS among East Asians; Statistically significant based on a Bonferroni-corrected threshold of P < 4.5 × 10−4 from 112 tests (0.05/112).
bDistance between a gene with the closest lead variant identified from previous CRC GWAS.
c P value derived from association analyses in TWAS after adjusting for the closest lead variant of each locus.
dPrediction performance (R2) was derived from miRNA expression prediction model building using small RNA sequencing and genotype data from 313 samples.