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. 2023 Nov 7;33(4):355–373. doi: 10.1093/hmg/ddad188

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© The Author(s) 2023. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Modulation of constitutively active GluD1 and GluD2 M3 variants by extracellular Ca²⁺. Representative Ca²⁺ concentration-response curves for (A) GluD1-A650T and (B) GluD2-A654T. The dotted line represents zero current. (C–F) Ca²⁺ concentration-response of GluD1-A650T, GluD2-A654D, GluD2-L656V, GluD2-T649A, and GluD2-A654T. For each experiment, same day control curves recorded for the lurcher variant GluD2-A654T are shown. All recordings normalized to NMDG⁺ − Na⁺ difference current. Unlike GluD2-A654T, GluD1-A650T and GluD2-A654D were modestly inhibited by Ca²⁺.