Table 5.
Channel blockers of constitutively active GluD1 and GluD2 current.
| Pentamidine IC50 (μM) | Memantine IC50 (μM) | |
|---|---|---|
| GluD1-A650T | 20 [16, 23] (10) | > 300 |
| GluD2-A654T | 9.6 [7.1, 11] (13) | 89 [60, 104] (14) |
| GluD2-T649A | 0.036 [0.014, 0.039] (15) | ND |
| GluD2-L656V | 10 [6.7, 12] (12) | ND |
| GluD2-A654D | 3.7 [2.6, 4.4] (13) | 55 [31, 87] (5) |
Data are mean [95% CI Lower, Upper] (n), where confidence intervals were determined from log IC50 values. See Fig. 10 for related concentration inhibition curves. ND indicated no data is available.