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Overview of the structure and major signal transduction pathways of TRK. (A) A cartoon shows three domains of TRK: an extracellular domain containing two cysteine-rich clusters (C1, C2), three leucine-rich regions (LRR1‒3), two immunoglobulin-like domains (Ig1, Ig2); a transmembrane domain (TM) and an intracellular kinase domain (KD). (B) TRK mediates the activation of RAS–RAF–MEK–ERK, PI3K–AKT, and PLC-γ1–DAG–PKC signaling pathways.
