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Representative point mutations in the KD of TRKA (PDB code 7VKN) (A); TRKB (PDB code 4ASZ) (B); TRKC (PDB code 6KZD) (C). The solvent-front (SF), gatekeeper (GK), xDFG substitutions are shown in cyan, magenta, yellow spheres, respectively. Mutations detected in patients are shown in red font. Resistance mechanisms caused by SF mutations (D); GK mutations (E); xDFG mutations (F).
