Table 4. Cox regression analysis of clinical outcomes in LUAD patients based on clinicopathologic features including DLX1 levels.
Bold numbers represent significant values. Footnotes *, ** and *** in Table 4: Ns: p > 0.05,*p ¡ 0.05, **p < 0.01, ***p < 0.001.
| Characteristics | HR for overall survival (95% CI) | HR for disease specific survival (95% CI) | HR for progress-free Interval (95% CI) | |||
|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | Univariate | Multivariate | |
| T stage (T1/T2 vs. T3/T4) | 1.728 ∗∗ | 1.273 | 1.85 ∗∗ | 1.237 | 1.882 ∗∗∗ | 1.342 |
| N stage (N0 vs. N1/N2/ N3) | 2.601 ∗∗∗ | 1.411 | 2.703 ∗∗∗ | 1.429 | 1.512 ∗∗ | 0.932 |
| M stage (M0 vs. M1) | 2.136 ∗∗ | 1.021 | 2.455 ∗∗ | 0.945 | 1.513 | |
| Pathologic stage (Stage I & Stage II vs. Stage III & Stage IV) | 2.664 ∗∗∗ | 2.097 ∗ | 2.436 ∗∗∗ | 2.314 ∗ | 1.513 ∗ | 1.046 |
| Primary therapy outcome (PD & SD & PR vs. CR) | 0.372 ∗∗∗ | 0.318 ∗∗∗ | 0.25 ∗∗∗ | 0.225 ∗∗∗ | 0.273 ∗∗∗ | 0.247 ∗∗∗ |
| Gender (Female vs. Male) | 1.07 | 0.989 | 1.172 | |||
| Age (≤65 vs. >65) | 1.223 | 1.013 | 1.023 | |||
| Residual tumor (R0 vs. R1 & R2) | 3.879 ∗∗∗ | 4.398 ∗∗∗ | 4.743 ∗∗∗ | 7.396 ∗∗∗ | 3.091 ∗∗∗ | 2.526 ∗ |
| Smoker (No vs. Yes) | 0.894 | 1.04 | 0.968 | |||
| DLX1 (Low vs. High) | 1.548 ∗∗ | 1.637 ∗ | 2.047 ∗∗∗ | 2.181 ∗∗ | 1.615 ∗∗∗ | 1.948 ∗∗∗ |