TABLE 1.
Significant associations of viral read counts and AD risk.
| Virus | Tissue | Dataset 1 | Odds ratio | p‐Value | Adjusted p‐value | Effect direction 2 |
|---|---|---|---|---|---|---|
| HSV‐1 3 | Meta‐analysis | Meta‐analysis | 3.69 | 6.71 × 10‐5 | 6.71 × 10‐4 | –++ |
| Blood | WES | 4.08 | 3.58 × 10‐5 | 3.58 × 10‐4 | + | |
| WGS | 0.49 | 0.64 | 1 | – | ||
| Brain | WES | 4.83 | 0.44 | 1 | + | |
| WGS | 1.80 × 10‐5 | 0.26 | 1 | – | ||
| HPV‐71 3 | Meta‐analysis | Meta‐analysis | 3.55 | 3.41 × 10‐3 | 0.03 | –+‐ |
| Blood | WES | 3.9 | 1.97 × 10‐3 | 0.02 | + | |
| WGS | 3.09 × 10‐100 | 0.93 | 1 | – | ||
| Brain | WES | 0.16 | 0.47 | 1 | – | |
| WGS | 1.83 × 10126 | 0.98 | 1 | + |
*Results from blood and brain anaylzed by dataset (WES/WGS) and combined by meta‐analysis.
† + indicates virus associated with increased AD risk,—indicates lower risk. The order of datasets is WES‐blood, WES‐brain, WGS‐blood, WGS‐brain.
‡ p‐values adjusted for 10 tests.