TABLE 2.

Association of viral phylogenetic clusters with AD by ancestry and DNA source.

			Herpes cluster *		Torque teno cluster †		Retrovirus cluster ‡
	Subset		Odds ratio	p‐Value §	Odds ratio	p‐Value §	Odds ratio	p‐Value §
WES	Total		1.10	0.42	1.40	0.01	0.30	0.09
	Ancestry	African American	0.82	0.29	1.67	8.73 × 10‐3	0.50	0.52
		Caribbean hispanic	1.89	0.11	0.90	0.78	4.02 × 10‐7	0.98
		European	1.22	0.27	1.20	0.45	0.30	0.33
	Body tissue source	Blood	1.02	0.85	1.39	0.02	0.36	0.18
		Brain	4.16	9.54 × 10‐3	2.53 × 10 7	0.99	0.04	0.04
WGS	Total		1.80	0.04	1.29	0.04	0.57	0.45
	Ancestry	African American	0.71	0.58	1.46	0.03	0.73	0.72
		Caribbean hispanic	1.48	0.06	0.95	0.83	NA	NA
		European	2.82	3.4 × 10‐3	1.58	0.10	2.53	0.59
	Body Tissue Source	Blood	2.30	8.79 × 10‐3	1.29	0.03	0.61	0.50
		Brain	1.89 × 10‐5	0.99	4.21x10 6	0.99	NA	NA

^*Includes HSV‐1, HSV‐2, HSV‐3, EBV, CMV, HHV‐6A, HHV‐6B, HHV‐7, and HHV‐8.

^† Includes TTV‐1, TTV‐2, TTV‐3, TTV‐5, TTV‐6, TTV‐7, TTV‐8, TTV‐9, TTV‐10, TTV‐11, TTV 12,TTV‐14, TTV‐25, TTV‐27, and TTV‐ALA22.

^‡ Includes HIV, human endogenous retrovirus K, primate T‐lymphotropic virus 1, and primate T‐lymphotropic virus 2.

^§ p < 0.01 significant level after Bonferroni correction of five tests.

NA = viral family not detected.