FIGURE 5.

An illustrative summary of the key findings. (A) The temporal coupling of a single theta burst (TB) event and a single spindle (SP) event to the trough of a slow wave (SW) event is re‐illustrated from Figure 1 as a conceptual reference. (B) An illustration of reduced electroencephalography (EEG) power in TB events that are coupled to both high transition frequency and low transition frequency SW events (illustration not to scale). Individuals with symptoms of mild cognitive impairment by Clinical Dementia Rating Scale (CDR) testing exhibit relatively lower EEG power of TB events. (C) A conceptual illustration of TB temporal and frequency precision “drift” in the coupling of TB events to high transition frequency SW events (illustration not to scale). Lower precision in this SW‐TB circuit is associated with categorical amyloid positivity by cerebrospinal fluid (CSF) threshold levels, as well as higher CSF levels of Aβ₄₂/Aβ₄₀, phosphorylated‐tau₁₈₁, and total‐tau. (D) A conceptual illustration of SP temporal and frequency precision “drift” in the coupling of SP events to low transition frequency SW events (illustration not to scale). Lower precision in this SW‐SP circuit is associated with categorical amyloid positivity by CSF threshold levels, as well as higher CSF levels of Aβ₄₂/Aβ₄₀. Aβ = amyloid.