TABLE 3.

Precision and TF‐window results.

	Perfect difference estimate	Adjusted confidence interval	Adjusted p‐value
Aβ+CU vs. Aβ‐CU
High transition frequency SW‐TB precision	−2.568	−4.993 to −0.081	0.041
High transition frequency SW‐SP precision	−3.042	−7.815 to 1.979	0.319
Low transition frequency SW‐TB precision	−1.938	−4.126 to 0.301	0.104
Low transition frequency SW‐SP precision	−5.099	−8.770 to −1.280	0.006
High transition frequency SW‐TB TF‐window	−0.448	−3.710 to 2.924	0.946
High transition frequency SW‐SP TF‐window	1.395	−2.256 to 5.182	0.645
Low transition frequency SW‐TB TF‐window	−0.097	−3.497 to 3.423	0.998
Low transition frequency SW‐SP TF‐window	0.848	−2.754 to 4.583	0.847
Aβ+CI vs. Aβ‐CU
High transition frequency SW‐TB precision	−1.707	−5.336 to 2.060	0.517
High transition frequency SW‐SP precision	−4.676	−10.916 to 2.002	0.213
Low transition frequency SW‐TB precision	−2.032	−4.814 to 0.832	0.210
Low transition frequency SW‐SP precision	−4.853	−10.896 to 1.600	0.170
High transition frequency SW‐TB TF‐window	−6.561	−10.146 to −2.834	<0.001
High transition frequency SW‐SP TF‐window	−1.083	−5.364 to 3.393	0.826
Low transition frequency SW‐TB TF‐window	−6.446	−10.471 to −2.241	0.002
Low transition frequency SW‐SP TF‐window	−0.393	−4.728 to 4.139	0.976
Aβ+CI vs. Aβ+CU
High transition frequency SW‐TB precision	0.883	−2.742 to 4.644	0.832
High transition frequency SW‐SP precision	−1.685	−8.104 to 5.182	0.818
Low transition frequency SW‐TB precision	0.259	−2.886 to 2.774	0.996
Low transition frequency SW‐SP precision	−0.096	−6.016 to 6.953	0.995
High transition frequency SW‐TB TF‐window	−6.141	−9.537 to −2.617	<0.001
High transition frequency SW‐SP TF‐window	−2.444	−6.566 to 1.860	0.360
Low transition frequency SW‐TB TF‐window	−6.356	−10.175 to −2.374	0.001
Low transition frequency SW‐SP TF‐window	−1.230	−5.412 to 3.136	0.772

	Correlation Estimate	95% Confidence Interval	p‐value
CSF 42/40 & Coupling Precision
High transition frequency SW‐TB coupling	0.197	0.060 to 0.327	0.005 *
High transition frequency SW‐SP coupling	0.140	0.001 to 0.273	0.047
Low transition frequency SW‐TB coupling	0.151	0.012 to 0.284	0.033
Low transition frequency SW‐SP coupling	0.183	0.046 to 0.314	0.009 *
p‐Tau181 & Coupling Precision
High transition frequency SW‐TB coupling	−0.201	−0.330 to −0.064	0.004 *
High transition frequency SW‐SP coupling	−0.091	−0.255 to 0.019	0.089
Low transition frequency SW‐TB coupling	−0.121	−0.226 to 0.049	0.201
Low transition frequency SW‐SP coupling	−0.134	−0.267−0.005	0.059
total Tau & Coupling Precision
High transition frequency SW‐TB coupling	−0.175	−0.306 to −0.037	0.013 *
High transition frequency SW‐SP coupling	−0.056	−0.193 to 0.084	0.432
Low transition frequency SW‐TB coupling	−0.033	−0.171 to 0.106	0.640
Low transition frequency SW‐SP coupling	−0.123	−0.257 −0.016	0.082
Combined SW‐TB/SW‐SP metric
Precision correlation with Aβ42/Aβ40	0.273	0.132 to 0.390	<0.001 *
Precision correlation with p‐tau181	−0.21	−0.073 to 0.339	0.003 *
Precision correlation with total‐tau	−0.182	−0.044 to −0.313	0.01 *

Note: Precision of coupling and TF‐window EEG power are expressed as a percent difference between groups, adjusted for covariates, and controlled for multiple comparisons with via Tukey‐Kramer adjustment. Correlations between precision of coupling and biomarkers are adjusted for covariates only.

Abbreviations: Aβ = amyloid; CU = cognitively unimpaired; CI = cognitively impaired; IQR = interquartile range; SP = spindle; SW = slow wave; TB = theta burst; TF = time‐frequency.