Table 2.
Summary of significant SNP-disease interactions for invasive melanoma (M-inv; top panel) and basal cell carcinoma (BCC; bottom panel).
Chr | SNP | Allele | Odds Ratio | P-value (FDR) | Gene | Location |
---|---|---|---|---|---|---|
16 | rs9926296 | A | 0.809446 | 3.77E-12 | FANCA | intron 31 |
16 | rs3743860 | C | 1.1965 | 1.29E-08 | FANCA | intron 31 |
16 | rs2376883 | A | 0.848934 | 1.92E-06 | FANCA | intron 29 |
Chr | SNP | Allele | Odds Ratio | P-value (FDR) | Gene | Location |
| ||||||
1 | rs12046289 | A | 0.914388 | 0.000104 | DCLRE1B | intron 2 |
1 | rs4149909 | G | 1.12746 | 0.021555 | EXO1 | exon 7 |
6 | rs61748588 | A | 1.18706 | 0.049773 | GTF2H4 | exon 5 |
8 | rs28928581 | C | 1.08347 | 0.043767 | RRM2B | intron 5 |
13 | rs4942486 | T | 1.0483 | 0.011646 | BRCA2 | intron 21 |
14 | rs4902628 | C | 0.958423 | 0.046463 | RAD51B | intron 11 |
16 | rs9926296 | A | 0.920691 | 2.42E-09 | FANCA | intron 31 |
16 | rs3743860 | C | 1.07056 | 5.88E-06 | FANCA | intron 31 |
16 | rs2376883 | A | 0.939527 | 0.000104 | FANCA | intron 29 |
16 | rs1800347 | C | 1.11993 | 0.004734 | FANCA | intron 33 |
16 | rs62989960 | T | 0.874634 | 0.004734 | FANCA | intron 25 |
Odds ratios represent the probability of the tested minor allele of each SNP to be found in the disease versus healthy control group. Significance for each allele has been determined using the False Discovery Rate (FDR) method. Each SNP is annotated for its chromosomal position (Chr), the localizing gene, and its location (intron or exon) within the gene.