Table 1.
Characteristics of the 653 incident Mass General Brigham Biobank RA cases and 2,607 matched controls with GWAS data and at least 5 years of EHR history
| Characteristic | RA cases (n=653) | Controls (n=2607) | p-value |
|---|---|---|---|
| Age in years, mean (SD) | 54 (13) | 54 (12) | * |
| Female sex, n (%) | 494 (76) | 1971 (76) | * |
| EHR history in years, median (IQR) | 12 (9,17) | 12 (8,16) | * |
| Enrollment year, median (IQR) | 2015 (2014–2017) | 2016 (2014–2017) | <0.001 |
| Race and ethnicity, n (%) | <0.0001 | ||
| Asian | 18 (3) | 50 (2) | |
| Black | 49 (8) | 91 (4) | |
| Hispanic | 9 (1) | 20 (1) | |
| Other | 20 (3) | 43 (2) | |
| White, non-Hispanic | 529 (85) | 2344 (92) | |
| Education college or higher, n (%)** | 377 (58) | 1882 (72) | <0.001 |
| BMI, kg/m2, mean (SD) | 29 (7) | 28 (6) | <0.001 |
| Smoking status, n (%)** | <0.001 | ||
| Never | 320 (49) | 1526 (59) | |
| Past | 274 (42) | 949 (36) | |
| Current | 59 (9) | 132 (5) | |
| Smoking pack-years, mean (SD)** | 10 (20) | 6.6 (13) | <0.001 |
BMI = body mass index, CI = confidence interval, EHR = electronic health record, GWAS = genome-wide association study, IQR = interquartile range, kg = kilograms, m = meters, RA = rheumatoid arthritis, SD = standard deviation
*
Matching factor
**
As of Mass General Brigham Biobank enrollment