Table 5.
Interaction between MUC5B promoter variant and respiratory tract diseases for incident seropositive RA risk
| MUC5B-Respiratory Interactions | ||||||
|---|---|---|---|---|---|---|
| Respiratory tract disease | MUC5B-/Resp+ | MUC5B+/Resp− | MUC5B+/Resp+ | AP (95% CI) | RERI (95% CI) | Multiplicative OR |
| Any respiratory tract disease | 1.07 (0.80,1.44) | 1.19 (0.73,1.93) | 1.04 (0.59,1.82) | −0.21 (−1.04,0.62) | −0.22 (−1.02,0.57) | 0.81 (0.40,1.67) |
| Asthma | 1.03 (0.68,1.58) | 0.95 (0.63,1.43) | 2.58 (1.10,6.07) | 0.62 (0.24,1.00) | 1.60 (−0.61,3.81) | 2.64 (0.98,7.09) |
| Interstitial lung disease | 2.71 (0.53,13.8) | 1.07 (0.73,1.57) | 1.97 (0.34,11.4) | −0.41 (−1.00,1.00) | −0.80 (−6.40,4.79) | 0.68 (0.06,7.57) |
| Pharyngitis | 1.43 (0.89,2.30) | 1.11 (0.75,1.65) | 1.22 (0.42,3.53) | −0.26 (−1.00,1.19) | −0.32 (−1.81,1.16) | 0.77 (0.23,2.52) |
| Acute pharyngitis | 1.41 (0.83,2.40) | 1.12 (0.76,1.64) | 1.10 (0.26,4.65) | −0.40 (−1.00,1.00) | −0.44 (−2.20,1.33) | 0.69 (0.15,3.28) |
| Chronic rhinitis/pharyngitis | 1.45 (0.65,3.27) | 1.06 (0.72,1.56) | 1.88 (0.50,7.12) | 0.20 (−1.00,1.00) | 0.37 (−2.39,3.13) | 1.22 (0.25,5.92) |
| Pneumonia and acute lower diseases | 1.44 (0.92,2.24) | 1.12 (0.75,1.66) | 1.18 (0.42,3.35) | −0.31 (−1.00,1.00) | −0.37 (−1.79,1.05) | 0.74 (0.23,2.37) |
| Sinusitis | 1.31 (0.77,2.22) | 1.04 (0.70,1.55) | 1.77 (0.71,4.42) | 0.24 (−0.54,1.00) | 0.43 (−1.29,2.14) | 1.31 (0.45,3.78) |
| Acute sinusitis | 1.17 (0.58,2.36) | 1.04 (0.70,1.54) | 2.05 (0.62,6.83) | 0.41 (−0.41,1.00) | 0.84 (−1.74,3.42) | 1.69 (0.41,6.94) |
| Chronic sinusitis | 1.16 (0.59,2.28) | 1.04 (0.70,1.54) | 2.00 (0.69,5.80) | 0.40 (−0.34,1.00) | 0.80 (−1.42,3.03) | 1.66 (0.47,5.87) |
CI = confidence interval, N/A = not applicable due to sample size, OR = odds ratio, RA = rheumatoid arthritis
*
Reference group was individuals without respiratory tract disease exposure and lowest two GRS tertiles. Adjusting for age, sex, EHR history, enrollment year, race and ethnicity by principal components, education, body mass index, smoking status, and pack-years. Bold values are statistically significant.