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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: Drug Resist Updat. 2023 Aug 21;71:101004. doi: 10.1016/j.drup.2023.101004

Figure 1. Signal transduction pathways related to ABC transporters (ABCB1, ABCG2, and ABCC1):

Figure 1.

Schematic illustration showing signaling pathways and their transcription factors (TFs) regulating gene expression of ABC transporters. TFs such as STAT3, Gli, YAP/TAZ, NRF2, NF-κB, β-catenin/TCF, Csl, and ERK 1/2 play a pivotal role in the signaling pathways that activate MDR-linked ABC transporter expression during the development of drug-resistant cancer. After transcription, ABC transporter proteins are translocated to the endoplasmic reticulum for folding and post-translational modifications (PTM). ABC transporter proteins are glycosylated in the Golgi apparatus and trafficked to the cell membrane. Finally, the ABC transporter proteins are translocated to the plasma membrane and are involved in the drug-efflux function.