Table 3.
Associations of alcohol consumption around breast cancer diagnosis and recurrence in the Pathways Study, stratified by estrogen-related factors
| Premenopausal | Postmenopausal | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n=1059 (162 events) | n=2600 (362 events) | ||||||||||
| n | events | HRa,b | 95% CI | n | events | HRa,b | 95% CI | ||||
| Non-drinker (<0.36 g/day) | 388 | 55 | Ref | Ref | Ref | 964 | 131 | Ref | Ref | Ref | |
| Occasional (0.36-<6 g/day) | 355 | 63 | 1.18 | 0.79 | 1.75 | 856 | 128 | 1.13 | 0.87 | 1.46 | |
| Regular (≥6 g/day) | 316 | 44 | 1.13 | 0.71 | 1.77 | 780 | 103 | 1.05 | 0.78 | 1.40 | |
| p for trend | .58 | .71 | |||||||||
| p for interaction=.97 | |||||||||||
| Continuous 6 g/day | 1059 | 162 | 1.00 | 0.98 | 1.02 | 2600 | 362 | 1.00 | 0.99 | 1.01 | |
| ER-negative | ER-positive | ||||||||||
| n=586 (105 events) | n=3071 (419 events) | ||||||||||
| n | events | HRa,b | 95% CI | n | events | HRa,b | 95% CI | ||||
| Non-drinker (<0.36 g/day) | 227 | 39 | Ref | Ref | Ref | 1123 | 147 | Ref | Ref | Ref | |
| Occasional (0.36-<6 g/day) | 207 | 40 | 0.92 | 0.57 | 1.50 | 1004 | 151 | 1.18 | 0.93 | 1.51 | |
| Regular (≥6 g/day) | 152 | 26 | 0.90 | 0.51 | 1.59 | 944 | 121 | 1.11 | 0.85 | 1.46 | |
| p for trend | .71 | .38 | |||||||||
| p for interaction=.88 | |||||||||||
| Continuous 6 g/day | 586 | 105 | 1.00 | 0.98 | 1.02 | 3071 | 419 | 1.00 | 0.99 | 1.01 | |
| Obese (BMI≥30 kg/m2) | Non-obese (BMI<30 kg/m2) | ||||||||||
| n=1222 (192 events) | n=2437 (332 events) | ||||||||||
| n | events | HRa,b | 95% CI | n | events | HRa,b | 95% CI | ||||
| Non-drinker (<0.36 g/day) | 529 | 88 | Ref | Ref | Ref | 823 | 98 | Ref | Ref | Ref | |
| Occasional (0.36-<6 g/day) | 430 | 69 | 0.96 | 0.68 | 1.36 | 781 | 122 | 1.29 | 0.97 | 1.71 | |
| Regular (≥6 g/day) | 263 | 35 | 0.90 | 0.58 | 1.40 | 833 | 112 | 1.19 | 0.88 | 1.62 | |
| p for trend | .65 | .27 | |||||||||
| p for interaction=.09 | |||||||||||
| Continuous 6 g/day | 1222 | 192 | 1.00 | 0.99 | 1.02 | 2437 | 332 | 1.00 | 0.99 | 1.01 | |
Adjusted for age at diagnosis, AJCC stage, race/ethnicity, education, menopausal status at diagnosis, nulliparity at diagnosis, hormone receptor status, surgery, treatment (radiation therapy, chemotherapy, hormonal therapy), smoking status at diagnosis, physical activity at diagnosis, BMI at diagnosis, comorbidity at diagnosis history of alcohol dependence at diagnosis, and neighborhood SES, while excluding menopausal status, hormone receptor status, and BMI as appropriate depending on stratified model.
For recurrence models, censored at first of KPNC health plan disenrollment or Pathways Study drop-out, death, or end of study (December 31, 2021).
NOTE: 0.36 g/day and 6 g/day of ethanol are approximately 0.25 drinks/week and 3.5 drinks/week, respectively