Table 5.
Associations of alcohol consumption around breast cancer diagnosis and all-cause mortality in the Pathways Study, stratified by estrogen-related factors
| Premenopausal | Postmenopausal1 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n=1059 (150 events) | n=2600 (684 events) | ||||||||||
| n | events | HRa,b | 95% CI | n | events | HRa,b | 95% CI | ||||
| Non-drinker (<0.36 g/day) | 388 | 58 | Ref | Ref | Ref | 964 | 284 | Ref | Ref | Ref | |
| Occasional (0.36-<6 g/day) | 355 | 57 | 1.17 | 0.78 | 1.75 | 856 | 211 | 0.94 | 0.78 | 1.13 | |
| Regular (≥6 g/day) | 316 | 35 | 0.93 | 0.58 | 1.50 | 780 | 189 | 0.89 | 0.72 | 1.09 | |
| p for trend | .87 | .25 | |||||||||
| p for interaction=.42 | |||||||||||
| Continuous 6 g/day | 1059 | 150 | 0.99 | 0.97 | 1.01 | 2600 | 684 | 1.00 | 0.99 | 1.00 | |
| ER-negative | ER-positive | ||||||||||
| n=586 (155 events) | n=3071 (679 events) | ||||||||||
| n | events | HRa,b | 95% CI | n | events | HRa,b | 95% CI | ||||
| Non-drinker (<0.36 g/day) | 227 | 64 | Ref | Ref | Ref | 1123 | 278 | Ref | Ref | Ref | |
| Occasional (0.36-<6 g/day) | 207 | 59 | 0.97 | 0.65 | 1.43 | 1004 | 209 | 0.97 | 0.80 | 1.17 | |
| Regular (≥6 g/day) | 152 | 32 | 0.72 | 0.43 | 1.18 | 944 | 192 | 0.94 | 0.77 | 1.16 | |
| p for trend | .23 | .56 | |||||||||
| p for interaction=.39 | |||||||||||
| Continuous 6 g/day | 586 | 155 | 0.98 | 0.96 | 1.00 | 3071 | 679 | 1.00 | 0.99 | 1.00 | |
| Obese (BMI≥30 kg/m2) | Non-obese (BMI<30 kg/m2) | ||||||||||
| n=1222 (321 events) | n=2437 (513 events) | ||||||||||
| n | events | HRa,b | 95% CI | n | events | HRa,b | 95% CI | ||||
| Non-drinker (<0.36 g/day) | 529 | 164 | Ref | Ref | Ref | 823 | 178 | Ref | Ref | Ref | |
| Occasional (0.36-<6 g/day) | 430 | 100 | 0.71 | 0.54 | 0.94 | 781 | 168 | 1.22 | 0.97 | 1.53 | |
| Regular (≥6 g/day) | 263 | 57 | 0.77 | 0.56 | 1.08 | 833 | 167 | 1.03 | 0.81 | 1.31 | |
| p for trend | .04 | .80 | |||||||||
| p for interaction=.05 | |||||||||||
| Continuous 6 g/day | 1222 | 321 | 0.99 | 0.98 | 1.00 | 2437 | 513 | 1.00 | 0.99 | 1.00 | |
Adjusted for age at diagnosis, AJCC stage, race/ethnicity, education, menopausal status at diagnosis, nulliparity at diagnosis, hormone receptor status, surgery, treatment (radiation therapy, chemotherapy, endocrine therapy), smoking status at diagnosis, physical activity at diagnosis, BMI at diagnosis, comorbidity at diagnosis, neighborhood SES, and history of alcohol dependence at diagnosis, while excluding menopausal status, hormone receptor status, and BMI as appropriate depending on stratified model.
For all-cause mortality models, censored at end of study (December 31, 2021).
NOTE: 0.36 g/day and 6 g/day of ethanol are approximately 0.25 drinks/week and 3.5 drinks/week, respectively