. Author manuscript; available in PMC: 2025 Jan 1.

Published in final edited form as: Trends Cancer. 2023 Sep 17;10(1):65–75. doi: 10.1016/j.trecan.2023.08.012

Table I.

Inducible degradation tag platforms

Degron tag	Protein tag	kDa	Drug/ligase target	Refs
Achilles tag	MTH1	19	aTAG 2139 – CRBN aTAG 4531 – CRBN	[74]
Auxin inducible degron 2 (AID2)	mIAA17	7	Indole-3-acetic acid – OsTIR1F74G	[65,66]
BromoTag	BRD4-BD2^L387A	15	AGB1 – VHL AGB3 – VHL	[72]
dTAG	FKBP12^F36V	12	dTAG-7 – CRBN dTAG-13 – CRBN dTAG-47 – CRBN dTAGV-1 – VHL	[70,71,77]
HaloTag	Halo	34	HaloPROTAC3 – VHL	[67–69]
IKZF3d	IKZF3	7	Pomalidomide – CRBN	[73]
Shield	FKBP12^F36V	12	Shield-1	[63,64]
SMASh	NS3 pro-NS4A	34	Asunaprevir	[85]