Table 2.

ALD vs NAFLD predictors.

Marker	AUC	Youden	Threshold	Sens	Spec	Acc	PPV	NPV	p value DeLong’s test
Scopulariopsis/S. cordiae (SCO)	0.68	0.35	>0.0020%	0.38	0.97	0.72	0.92	0.68
Kluyveromyces (K)	0.67	0.33	>0.0022%	0.40	0.94	0.71	0.82	0.68
Mucor (M)	0.65	0.32	<0.0031%	0.95	0.37	0.62	0.53	0.91
Saccharomyces/S. cerevisiae	0.59	0.30	>91.38%	0.36	0.94	0.69	0.81	0.66
Kazachstania	0.66	0.33	<0.0024%	0.90	0.44	0.63	0.54	0.85
M. restricta (MR)	0.70	0.41	>0.00026%	0.48	0.92	0.74	0.82	0.71
C. albicans	0.64	0.30	>0.00026%	0.62	0.68	0.65	0.59	0.71
C. argentea	0.59	0.18	<0.00001%	0.97	0.22	0.54	0.48	0.90
SCO+K	0.80	0.58	SCO > 0.0020%, K > 0.0022%	0.67	0.91	0.81	0.85	0.79	<0.001 vs SCO
SCO+K+MR	0.89	0.76	SCO > 0.0020%, K > 0.0022%, MR > 0.00026%	0.93	0.83	0.88	0.81	0.94	0.007 vs SCO+K
SCO+K+MR+M	0.93	0.82	SCO >0.0020%, K > 0.0022%, MR  > 0.00026%, M < 0.0031%	0.91	0.91	0.91	0.88	0.93	0.038 vs SCO+K+MR

The best threshold was determined to maximize the Youden index (= sensitivity + specificity − 1) for each marker. N = 136. Acc, accuracy; AUC, area under the curve; C., Candida; K, Kluyveromyces; M, Mucor; MR, Malassezia restricta; NPV, negative predictive value; PPV, positive predictive value; S. cerevisiae, Saccharomyces cerevisiae; SCO, Scopulariopsis/S. cordiae; sens, sensitivity; spec, specificity.