Table 3.
Baseline demographic and laboratory data of the study population stratified by fibrosis severity.
| n | ALD F0-F1 (n = 48) | ALD F2-F4 (n = 10) | NAFLD F0-F1 (n = 43) | NAFLD F2-F4 (n = 30) | p value | |
|---|---|---|---|---|---|---|
| Gender [male], n [%] | 131 | 33 (68.8%) | 7 (70.0%) | 22 (51.2%) | 14 (46.7%) | 0.154 |
| Age [years] | 131 | 42.0 [34.0;53.0] | 50.0 [43.2;62.5] | 52.3 [38.5;58.6] | 60.7 [55.2;66.0] | <0.001 |
| BMI [kg/m2 | 131 | 24.2 [21.9;26.6] | 25.5 [22.3;28.4] | 29.6 [27.0;31.2] | 31.4 [27.5;36.6] | <0.001 |
| AST [IU/L] | 131 | 47.5 [28.8;84.8] | 107 [64.5;178] | 30.0 [26.5;37.5] | 50.0 [33.2;63.2] | <0.001 |
| ALT [IU/L] | 131 | 39.5 [23.0;77.5] | 81.0 [46.8;93.5] | 44.0 [30.5;58.5] | 54.0 [34.0;84.0] | 0.135 |
| GGT [IU/L] | 131 | 90.0 [40.2;212] | 415 [259;896] | 83.0 [42.0;120] | 70.5 [49.5;124] | 0.002 |
| AP [IU/L] | 130 | 73.0 [61.0;86.0] | 88.0 [59.0;135] | 73.0 [61.0;93.0] | 77.5 [67.2;94.5] | 0.343 |
| Bilirubin [mg/dL] | 130 | 0.50 [0.30;0.60] | 0.55 [0.40;0.70] | 0.40 [0.30;0.70] | 0.60 [0.40;0.90] | 0.128 |
| Albumin [g/dL] | 129 | 4.65 [4.43;5.00] | 4.40 [4.03;4.57] | 4.50 [4.30;4.65] | 4.30 [4.03;4.47] | <0.001 |
| INR | 130 | 0.94 [0.89;1.01] | 1.11 [1.04;1.21] | 1.00 [0.90;1.00] | 1.00 [1.00;1.10] | <0.001 |
| Creatinine [mg/dL] | 131 | 0.81 [0.74;0.92] | 0.74 [0.71;0.81] | 0.85 [0.70;1.03] | 0.84 [0.70;0.98] | 0.361 |
| Platelets [109/L] | 130 | 240 [188;284] | 169 [136;230] | 250 [186;287] | 208 [146;250] | 0.028 |
| CAP [dB/m] | 84 | 308 [265;326] | 328 [295;347] | 279 [249;309] | 291 [269;325] | 0.321 |
| Stiffness [kPa] | 131 | 5.05 [3.98;6.12] | 17.2 [12.7;24.4] | 4.80 [4.40;5.55] | 13.7 [11.0;17.5] | <0.001 |
Values are presented as median and upper and lower quartiles in brackets. The number of subjects for which data were available is indicated in the first column. Continuous variables were compared using the Wilcoxon-Whitney-Mann rank-sum test. Categorical variables were compared using the Pearson’s Chi-squared test. Bold font indicates statistical significance (p < 0.05). ALT, alanine aminotransferase; AP, alkaline phosphatase; AST, aspartate aminotransferase; BMI, body mass index; CAP, controlled attenuation parameter; GGT, gamma-glutamyltransferase; INR, international normalized ratio.