Figure 3.

C. rodentium T2SS is necessary for successful infection in C3H/HeJ mice. (a) Weight loss post-infection in WT and T2SS-deficient strains, presented as a proportion of weight (g) measured before C. rodentium infection. n = 5 for each group, error bars indicate standard deviation. (b) Bacterial load of C. rodentium shed in the feces post-infection as determined by selective plating and counting CFU. n = 5 for each group, error bars indicate standard deviation. (c) Probability of survival represents the proportion of mice that have not reached the pre-determined humane endpoints with regards to infection symptoms. n = 5 for each group. Probability of survival in WT- and ΔgspK-infected mice was compared using the log rank test.