Table 5:

Longitudinal Associations Between TTV and Disability Measures. Significant p-values shown in bold, determined using Bonferroni correction for 6 outcomes (p<0.008). For interpretability, thalamic volumes are scaled by 10³ for LCVA-25, SDMT, 9-HPT, and MSFC-4; and by 10⁴ for EDSS and T25FW.

Mixed Effects Model: Longitudinal Associations Between TTV and Disability Measures
Predictor		EDSS	LCVA-25	SDMT	T25FW	9-HPT	MSFC-4
Thalamic volume — mm3	β	−0.616	0.912	4.295	2.848	−1.140	0.120
	P-value	0.306	0.129	<0.001	0.758	0.175	0.002
Timepoint	β	0.002	−0.020	−0.007	0.028	0.011	−0.001
	P-value	0.001	0.001	0.233	0.007	0.128	<0.001
Treatment group (Placebo)	β	−0.156	−2.239	−1.405	0.262	2.469	−0.141
	P-value	0.291	0.120	0.323	0.905	0.228	0.135
MS Subtype (SPMS)	β	0.167	−3.113	1.814	3.417	5.991	−0.218
	P-value	0.368	0.087	0.312	0.220	0.021	0.067
Disease duration	β	0.008	<0.001	0.019	0.072	−0.031	<0.001
	P-value	0.364	0.132	0.820	0.579	0.795	0.978
Age	β	−0.009	−0.161	−0.219	−0.256	−0.207	0.003
	P-value	0.422	0.132	0.039	0.118	0.172	0.693
Sex (F)	β	0.096	1.520	7.631	2.488	−10.363	0.371
	P-value	0.567	0.350	<0.001	0.319	<0.001	<0.001
Ethnicity (Not Hispanic)	β	0.206	4.309	8.663	−3.840	−0.066	0.332
	P-value	0.627	0.299	0.036	0.547	0.991	0.218
Intracranial volume1 — mm3	β	<0.001	<−0.001	<0.001	<−0.001	−0.001	<0.001
	P-value	0.953	0.855	0.520	0.515	0.385	0.313