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| loxP+/Cre+ | loxP–/Cre+ | |
|---|---|---|
| Number of replicate cultures | 10 | 10 |
| Initial number of cells per culture | 1 | 1 |
| Final number of cells per culture (mean) | 4.6 × 106 | 4.3 × 106 |
| Number of cells per sample | 1 × 106 | 1 × 106 |
| Mean of resistant colonies per samplea | 1026 | 45 |
| The rate of appearance of resistant colonies | 1.1 × 10–4 | 7.2 × 10–6 |
aG418 (750 µg/ml) was used for selection.
