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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: Lancet Respir Med. 2023 Aug 23;11(11):965–974. doi: 10.1016/S2213-2600(23)00237-0

Figure 3: Differential treatment response to activated protein C (APC) according to probability of belonging to the Hyperinflammatory phenotype.

Figure 3:

A logistic regression model was fit to predict mortality at Day 28 in the PROWESS-SHOCK trial, with the probability of belonging to the Hyperinflammatory phenotype (x-axis), treatment allocation, and their interaction term as predictor variables. The lines plot the estimated mortality in either placebo (red) or activated protein C (green) with 95% confidence intervals over a range of probabilities. P-value was generated using Wald test for the interaction term of probability and treatment allocation in the logistic regression model.