Table 1.

Univariable Cox analysis of factors associated with angiosarcoma overall survival. Abbreviations: PBA, Primary breast angiosarcoma; SBA, secondary breast angiosarcoma.

	SBA	PBA
Characteristics	HR (95%CI), p-value	HR (95%CI), p-value
Race
White	referent	referent
Black	0.97 (0.40–2.39), 0.953	1.50 (0.65–3.48), 0.346
Other (American Indian/ AK Native, Asian/ Pacific Islander)	0.85 (0.31–2.31), 0.746	0.86 (0.39–1.88), 0.698
Age at Diagnosis
Continuous	1.05 (1.03–1.06), <0.001	1.01 (1.00–1.02), 0.054
Size
Continuous	1.00 (1.00–1.01), 0.036	1.01 (1.01–1.01), <0.001
Tumor Grade
I	0.32 (0.11–0.89), 0.030	0.37 (0.17–0.78), 0.010
II	0.83 (0.44–1.59), 0.582	0.35 (0.17–0.70), 0.003
III	0.92 (0.56–1.49), 0.730	1.09 (0.58–2.05), 0.972
IV	referent	referent
Missing	0.79 (0.49–1.28), 0.340	0.39 (0.15–0.98), 0.046
Lymph node involvement
Negative	referent	referent
Positive	2.14 (0.67–6.82), 0.197	3.29 (1.30–8.30), 0.012
Unknown	1.52 (0.90–2.56), 0.120	1.19 (0.58–2.41), 0.637
Tumor Stage
Local	referent	referent
Regional	1.92 (1.31–2.82), 0.001	3.15 (1.84–5.40), <0.001
Primary Site
Nipple	2.11 (0.76–5.83), 0.152	n/a
Central portion of breast	1.46 (0.76–2.79), 0.252	0.78 (0.18–3.30), 0.736
Upper-inner quadrant of breast	0.84 (0.21–3.46), 0.815	0.35 (0.12–1.01), 0.052
Lower- inner quadrant of breast	1.62 (0.64–4.05), 0.306	0.37 (0.11–1.23), 0.104
Upper- outer quadrant of breast	0.47 (0.19–1.18), 0.107	0.55 (0.25–1.22), 0.140
Lower- outer quadrant of breast	1.11 (0.45–2.78), 0.820	0.33 (0.04–2.42), 0.275
Overlapping lesion of breast	1.42 (0.87–2.30), 0.161	1.06 (0.62–1.82), 0.831
Breast, NOS	referent	referent
Radiation
No/Unknown	referent	referent
Yes	0.72 (0.35–1.48), 0.374	1.21 (0.74–1.96), 0.445
Chemotherapy
No/Unknown	referent	referent
Yes	0.76 (0.47–1.21), 0.240	1.14 (0.68–1.90), 0.627