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. Author manuscript; available in PMC: 2024 Dec 1.
Published in final edited form as: Proteomics. 2023 Aug 21;23(23-24):e2100211. doi: 10.1002/pmic.202100211

FIGURE 1.

FIGURE 1

Small open reading frames (sORFs) and RNA. Box: Within mRNA that encodes canonical protein coding sequences (CDSs), sORFs can appear in the 5′ UTR (upstreamORF [uORF]), initiating in the 5′ UTR and extending into the CDS in an alternative reading frame (upstream overlapping ORF [u.oORF]), in the 3′ UTR (downstreamORF [dORF]), or nested within the CDS in an alternative reading frame. sORFs can also be found in long noncoding RNA (lncRNA, bottom) and circular RNA (circRNA, right), as well as additional classes of RNA not pictured.