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. Author manuscript; available in PMC: 2024 Dec 1.
Published in final edited form as: Anesthesiology. 2023 Dec 1;139(6):880–898. doi: 10.1097/ALN.0000000000004734

Table 2.

Medication Classes associated with Nephrotoxicity. ACEi, Angiotensin Converting Enzyme Inhibitors. ARBs, Angiotensin Receptor Blockers. NSAIDs, Non-steroidal anti-inflammatory drugs.

Medication Mechanism for Nephrotoxicity
ACEi and ARBs Functional renal insufficiency (Hypotension)
NSAIDS Reduction in prostaglandin synthesis
Antibiotics (Vancomycin, Aminoglycosides and Beta-lactams) Acute tubular necrosis, acute interstitial nephritis, Crystal-induced acute kidney injury
Intravenous contrast agents Acute tubular necrosis
Diuretics Hypovolemia and hypotension