Table 4. Comparison of 29-kDa TMEM106B core accumulation and TDP-43 subtype in FTLD-TDP.

β, regression coefficient; CI, confidence interval; min, minimum; max, maximum. β values, 95% CIs, and P values result from unadjusted linear regression models or linear regression models adjusted for age at death and sex, where 29-kDa TMEM106B abundance (measured as intensity of the 29-kDa band on Western blot of the sarkosyl insoluble fraction) was considered on the base 10 logarithmic scale. β values are interpreted as the difference in the 29-kda TMEM106B abundance between FTLD-TDP type A cases and the indicated subtypes. P < 0.025 was considered statistically significant after correcting for multiple testing.

		Unadjusted analysis		Adjusted analyses
TDP-43 type	Median 29-kDa TMEM106B levels (min, max)	β (95% CI)	P value	β (95% CI)	P value
A	47.64 (0, 470.6)	0.00 (reference)	NA	0.00 (reference)	NA
B	4.21 (0.13, 98.5)	−0.736 (−0.953 to −0.520)	<0.0001	−0.545 (−0.763 to −0.327)	<0.0001
C	13.25 (0, 148.9)	−0.456 (−0.703 to −0.209)	0.0003	−0.3946 (−0.631 to −0.159)	0.001