Table 5. Associations of 29-kDa TMEM106B with pTDP-43 and tSTMN2 RNA in FTLD-TDP.

β, regression coefficient; CI, confidence interval; RIN, RNA integrity number in the frontal cortex; tSTMN2 RNA, truncated STMN2 RNA concentration in the frontal cortex; pTDP-43 protein, phosphorylated TDP-43 protein concentration in the frontal cortex. β values, 95% CIs, and P values result from unadjusted linear regression models or linear regression models adjusted for the indicated variables. Twenty-nine–kilodalton TMEM106B abundance, pTDP-43 burden, and tSTMN2 RNA were considered on the base 10 logarithmic scale. β values are interpreted as the associations in 29-kDa TMEM106B abundance and the indicated variables. P < 0.025 was considered statistically significant after correcting for multiple testing.

	Unadjusted analysis		Multivariable analysis
	β (95% CI)	P-value	β (95% CI)	P-value	Adjusted for
pTDP-43 protein	0.248 (0.051–0.446)	0.0141	0.471 (0.288–0.653)	<0.0001	Age at death and sex
tSTMN2 RNA	0.638 (0.331–0.944)	<0.0001	0.758 (0.475–1.040)	<0.0001	Age at death, sex and RIN