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. Author manuscript; available in PMC: 2024 Nov 16.
Published in final edited form as: Mol Cell. 2023 Oct 5;83(22):3953–3971. doi: 10.1016/j.molcel.2023.09.016

Figure 1. Canonical and non-canonical tRNA functionality.

Figure 1.

Illustration of canonical tRNA function in decoding the genetic code of mRNAs and deliver cognate amino acids to the ribosome for protein synthesis. Shown also is the expanding non-canonical tRNA functions in the cell. These non-canonical functions leverage the structural features of tRNA to interact with specific proteins, thereby regulating cellular physiology and mediating critical viral-host interactions across various biological processes.