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. Author manuscript; available in PMC: 2024 Nov 16.
Published in final edited form as: Mol Cell. 2023 Oct 5;83(22):3953–3971. doi: 10.1016/j.molcel.2023.09.016

Figure 3. Structural plasticity in tRNAs and tsRNAs and their modulation by RNA modifications and cofactor binding.

Figure 3.

(A) Illustration showing how post-transcriptional RNA modifications and tRNA-binding proteins act to regulate RNase-mediated tRNA cleavage and tsRNA formation. (B) Schematic presentation of the conformational free-energy landscapes of tRNAs (left) and tsRNAs (right) and their modulation in response to changes e.g., in modification state or ligand binding. (C) Structural view of predicted tsRNAs derived from a single tRNAAla precursor.