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. Author manuscript; available in PMC: 2024 Nov 16.
Published in final edited form as: Mol Cell. 2023 Oct 5;83(22):3953–3971. doi: 10.1016/j.molcel.2023.09.016

Figure. 5. Integrating multi-layers of tsRNA information enables diverse tsRNA functionality.

Figure. 5

Multi-faceted data obtained from various technologies regarding tsRNA sequence/fragmentation pattern, site-specific RNA modifications, RNA structures, tsRNA binding proteins and subcellular compartmentalization would enable future high-dimensional analyses with the advancement of deep learning algorism, leading to better understand of the fundamental modes of tsRNA action, and thus their biological roles in specific contexts. RNase: ribonuclease; RNPs: ribonucleoprotein particles; EV: extracellular vesicle; Cyto: cytoplasma; Nuc: nucleus.