Table 2.
Pathologic and clinical variables associated with the presence of tumoral L. iners (N=96).
| Tumor L. Iners Status |
|||||
|---|---|---|---|---|---|
| Variable | L. iners − (N=52) | L. iners + (N=44) | |||
| N (%) |
Mean (SD) |
N (%) |
Mean (SD) |
p-valuea |
|
| Institution | 0.07 | ||||
| LBJ Hospitalb | 15 (29) | 6 (14) | |||
| MDACCc | 37 (71) | 38 (86) | |||
| Age (years) | 47.1 (9) | 43.0 (11) | 0.06 | ||
| Race | 0.21 | ||||
| Black/Asian/Other | 6 (12) | 6 (14) | |||
| Hispanic | 27 (52) | 15 (34) | |||
| White | 19 (37) | 23 (52) | |||
| BMId (kg/m2) | 30.2 (6) | 28.9 (7) | 0.34 | ||
| Smoking Status | 0.61 | ||||
| Never | 32 (62) | 26 (59) | |||
| Former | 14 (27) | 15 (34) | |||
| Current | 6 (12) | 3 (7) | |||
| Histology | 0.50 | ||||
| Non-squamouse | 10 (19) | 11 (25) | |||
| Squamous | 42 (81) | 33 (75) | |||
| LVSI f | 0.80 | ||||
| No | 12 (23) | 9 (21) | |||
| Yes | 3 (6) | 4 (9) | |||
| Unknown | 37 (71) | 31 (70) | |||
| FIGO 2009 Stage g | 0.37 | ||||
| I-II | 26 (50) | 26 (59) | |||
| III-IV | 26 (50) | 18 (41) | |||
| Grade | 0.08 | ||||
| Indeterminate/ Unknown | 7 (14) | 11 (25) | |||
| 1 | 6 (12) | 1 (2) | |||
| 2 | 25 (48) | 15 (34) | |||
| 3 | 14 (27) | 17 (39) | |||
| HPV Genotype | 0.11 | ||||
| HPV 16/18 | 35 (71) | 24 (56) | |||
| Negative/Other | 14 (29) | 19 (44) | |||
| Cisplatin Cycles | 5.0 (1) | 5.0 (1) | 0.92 | ||
| Antibiotic Use h | 0.12 | ||||
| No | 36 (69) | 23 (54) | |||
| Yes | 16 (31) | 20 (47) | |||
| Nodal Status | 0.98 | ||||
| Negative/Unknown | 20 (38) | 17 (39) | |||
| Positive | 32 (62) | 27 (61) | |||
| Tumor Dimension (cm) | 5.5 (2) | 5.1 (2) | 0.38 | ||
| Faith's PDi (Gut) | 12.1 (3) | 12.7 (3) | 0.30 | ||
| Fisher's Alpha (Gut) | 20.5 (9) | 23.0 (8) | 0.17 | ||
| Observed Features (Gut) | 150.8 (61) | 166.4 (58) | 0.22 | ||
| Pielou's Evenness (Gut) | 0.7 (0) | 0.7 (0) | 0.23 | ||
| Shannon Diversity (Gut) | 5.0 (1) | 5.2 (1) | 0.15 | ||
| Simpson's Evenness (Gut) | 0.1 (0) | 0.1 (0) | 0.53 | ||
| Simpson Diversity (Gut) | 0.9 (0) | 0.9 (0) | 0.36 | ||
a
Chi-square or Fisher’s exact test for categorical variables. T-test for continuous variables.
b
Lyndon B. Johnson Hospital, Harris Health System, Houston TX.
c
The University of Texas M.D. Anderson Cancer Center, Houston TX.
d
Body mass index.
e
Adenocarcinoma and adenosquamous carcinoma.
f
Lymphovascular space invasion.
g
The International Federation of Gynecology and Obstetrics.
h
Antibiotic use within 30 days of baseline swab collection extracted from inpatient and outpatient pharmacy and electronic medical record data, antifungals not included.