TABLE 2.
Myocardial triglyceride content in special populations.
| References | Clinical population | Results |
|---|---|---|
| Mahmod et al. (2013) | 39 aortic stenosis patients vs. 20 matched controls |
• mTG ↑ in severe aortic stenosis • mTG ↓ in patients after aortic valve replacement to concentrations similar to controls |
| Graner et al. (2015) | 75 non‐alcoholic fatty liver disease patients divided into tertiles according to hepatic TG |
• mTG ↑ with ↑ adiposity (BMI, hepatic TG, VAT, SAT, epi‐ and pericardial fat) |
| Brittain et al. (2016) | 6 pulmonary arterial hypertension vs. 8 controls |
• mTG ↑ in PAH • Despite higher FFA availability, PAH experience impaired FA utilization so that lipotoxicity ensued |
| Gizurarson et al. (2015) | 34 patients with atrial fibrillation vs. 17 controls | • mTG ↓ in atrial fibrillation when assessed directly from atrial biopsies |
| Nelson et al. (2013) | 6 generalized lipodystrophy patients vs. 6 matched controls | • mTG ↑ in generalized lipodystrophy with concurrent concentric LV hypertrophy |
| Wolf et al. (2021) | 23 Cushing's syndrome patients vs. 27 matched controls |
• mTG ↔ despite greater epi‐ and pericardial fat mass in patients • mTG ↔ after treatment and remission |
| Scherer et al. (2014) | 10 hypothyroidism patients vs. 10 matched controls |
• mTG ↔ • After levothyroxine treatment, mTG ↓ with concurrent improvements in LV morphology and filling dynamics |
| Winhofer, Wolf et al. (2014) | 10 acromegaly patients vs. 10 matched controls |
• mTG and hepatic TG ↔ but pericardial fat ↓ in acromegaly • After treatment, mTG and hepatic TG ↔ but pericardial fat ↑ |
| Wolf et al. (2014) | 8 familial hypocalcuric hypercalcaemia patients vs. 9 matched controls |
• mTG, hepatic TG, VAT, and SAT ↔ |
| Knottnerus et al. (2020) | 14 patients with long‐chain fatty acid β oxidation disorders vs. 14 matched controls |
• mTG ↔ |
| Gastl et al. (2019) | 11 cardiac amyloidosis patients vs. 11 matched controls | • mTG ↓ in cardiac amyloidosis |
BMI, body mass index; FA, fatty acid; FFA, free fatty acid; mTG, myocardial triglyceride content; PAH, pulmonary arterial hypertension; SAT, subcutaneous adipose tissue; TG, triglyceride; VAT, visceral adipose tissue.