Figure 5.

In vivo therapeutic efficacy of PONI-C11-TMA/siRNA polyplexes for severe wound biofilm infections. a) Schematic representation of the murine model of wound biofilm infection. b) SEM image of mice skin sample confirming biofilm formation at the wound site. Scale bar: 5 μm. c) Bioluminescence signals from the wound area of representative mice on the different days of treatment. d) Extent of bacterial reduction relative to negative control, PBS only [bacteria reduction = (log CFU count)PBS - (log CFU count)treatment group]. Error bars represent the mean ± the standard error of the mean (SEM) (n=4, one-way ANOVA and Tukey multiple comparisons, *p < 0.05).