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. Author manuscript; available in PMC: 2024 Nov 27.
Published in final edited form as: Mater Horiz. 2023 Nov 27;10(12):5500–5507. doi: 10.1039/d3mh01108a

Figure 6.

Figure 6.

Therapeutic efficacy of PONI-C11-TMA/siRNA polyplexes mediated gene knockdown to induce wound healing in vivo. a) Purulence scores of the mice treated with PBS, polymer (PONI-C11-TMA), polyplex (PONI-C11-TMA/si_MMP9 polyplex), or vancomycin on the day of sacrifice. Kruskal-Wallis test and Dunn’s multiple comparisons, *, ** indicate p-value < 0.05 or 0.01, respectively. b) In vivo treatment of PONI-C11-TMA/si_MMP9 decreased MMP9 mRNA levels quantified by qRT-PCR. Error bars represent the mean ± the standard error of the mean (SEM) (n=4, one-way ANOVA and Tukey multiple comparisons, ***p < 0.001. c) Degree of wound size reduction at the day of sacrifice relative to the first day of treatment. One-way ANOVA and Tukey multiple comparisons, *, **, *** indicate p-value < 0.05, 0.01 or 0.001, respectively.