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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: Nat Neurosci. 2023 Nov 23;27(1):34–47. doi: 10.1038/s41593-023-01496-0

Extended Data Figure 4: Axonal shrinkage, collapse of neurofilament spacing, and tearing of myelin in sporadic ALS and C9-ALS.

Extended Data Figure 4:

Representative electron microscopy images of large caliber axon cross sections in the motor roots of postmortem human samples from healthy controls n = 2 (upper panel) and sporadic ALS (sALS, n=5) and C9orf72 ALS patients (C9 ALS, n=2) (lower panel). Increased magnification micrographs of the axoplasm showing altered spacing between neurofilament filaments is shown.