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. Author manuscript; available in PMC: 2024 Dec 15.
Published in final edited form as: J Mol Biol. 2023 Nov 10;435(24):168365. doi: 10.1016/j.jmb.2023.168365

Figure 4. The asymmetric structure of the P22 tailspike.

Figure 4.

(A) The structure of the full-length P22 tailspike reveals an asymmetric NTD leaning to the left, connected to a triple β-helix body. (B) Superimposition of the tailspike N-termini (res 1–126). (C) Schematic diagram of the symmetry mismatch between the tail hub and trimer tailspikes. The red dashed line circles the pseudo-2:1 binding interface. (D) Quaternary structure of P22 tailspikes observed in the MV. Six tailspike (one subunit in red and five in light gray) are shown in a side view (left panel) and rotated along the y-axis by 90 degrees (right panel). The red dashes denote the smallest distance between adjacent tailspike subunits.