CbpD; AF278686
|
Sequence scanning |
Protein–protein interactions |
Loss of nasopharyngeal colonization |
Mutant strain: no reduction in virulence |
CbpE; AF278687
|
Sequence scanning |
|
Loss of nasopharyngeal colonization |
Mutant strain: no reduction in virulence |
CbpF; AF278688
|
Sequence scanning |
|
No effect on nasopharynx colonization |
Mutant strain: no reduction in virulence |
CbpG; AF278688
|
Sequence scanning |
Proteolysis of host macromolecules |
Loss of adherence to nasopharynx |
Mutant strain: 103 fold reduction in virulence |
CbpI; AF278689
|
Sequence scanning; DNA microarray |
|
No effect on nasopharynx colonization |
Mutant strain: no reduction in virulence |
CbpJ; AF278690
|
Sequence scanning; DNA microarray |
|
No effect on nasopharynx colonization |
Mutant strain: no reduction in virulence |
LytB; CAA09078
|
Sequence scanning |
Glucosaminidase |
Loss of adherence to nasopharynx |
Recombinant protein: protection from pneumococcal challenge |
LytC; CAA08765
|
Sequence scanning |
Lysozyme |
Loss of adherence to nasopharynx |
Recombinant protein: protection from pneumococcal challenge |
PavA; AF181976
|
Signature-tagged mutagenesis |
Fibronectin binding |
No binding to immobilized fibronectin |
Mutant strain: 104 fold attenuation in virulence |
SmcA (PBP1A-like) |
Signature-tagged mutagenesis |
Peptidoglycan metabolism |
|
Mutant strain: attenuation in virulence |
SmcB (YokZ-like) |
Signature-tagged mutagenesis |
Carboxypeptidation |
|
Mutant strain: attenuation in virulence |
SmcC (BacA-like) |
Signature-tagged mutagenesis |
Undecaprenyl recycling |
|
Mutant strain: attenuation in virulence |
PhtA; AF291695
|
Sequence scanning |
Metal/nucleoside binding |
|
Recombinant protein: limited protection from challenge |
PhtB; AF318954
|
Sequence scanning |
Metal/nucleoside binding |
|
Recombinant protein: limited protection from challenge |
PhtD; AF318955
|
Sequence scanning |
Metal/nucleoside binding |
|
Recombinant protein: protection from challenge with diverse streptococcal subtypes |
PhtE; AF318956
|
Sequence scanning |
Metal/nucleoside binding |
|
Recombinant protein: no protection against challenge |