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. Author manuscript; available in PMC: 2024 Feb 5.
Published in final edited form as: Cell Rep. 2023 Oct 18;42(10):113248. doi: 10.1016/j.celrep.2023.113248

Figure 3. Neutralizing antibodies elicited against group 2b and 2c betacoronaviruses.

Figure 3.

Live-virus neutralizing activity against (A) SARS-CoV-2 BA.1, (B) bat zoonotic WIV-1-CoV, (C) SARS-CoV Urbani, and (D) MERS-CoV EMC. Mouse sera at baseline and post-boost are shown in 2× vaccinated mice for SARS-CoV-2 BA.1, SARS-CoV Urbani, and MERS-CoV. Mouse sera post second boost were used against WIV-1. Blue circles denote monovalent SARS-CoV-2 RBD scNP-vaccinated mice. Magenta squares denote trivalent SARS-CoV-2/RsSHC014/MERS-CoV RBD scNP-vaccinated mice. Gray triangles denote adjuvant-only control mice. Numerical values in the graphs denote the median ID80 values. ID80 values are reported as reciprocal serum dilution that inhibits 80% of virus replication. A Kruskal-Wallis non-parametric test with Dunn’s multiple comparisons test was used throughout to compare the median ID80 values across vaccine groups (*p < 0.05, **p < 0.005, ***p < 0.0005, and ****p < 0.0001).