Figure 2: VEGF-A and Angiogenin secretion into cellular media after recipient cell’s exposure to Mp.
In vitro exposure of (A) tumor parenchyma (PC3WT) or (B) Endothelial cells and (C) macrophages (THP-1) with Mp for up to 24 hours, measured by protein array. Graphs show the average concentration of VEGF and Angiogenin. N=3 independent experiments for each (2-way ANOVA was used to compare all data, with WT-Mp acting as a control; ****P <0.0001 and *P=0.0472).