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. Author manuscript; available in PMC: 2024 Dec 1.
Published in final edited form as: J Control Release. 2023 Nov 2;364:312–325. doi: 10.1016/j.jconrel.2023.10.038

Figure 7: PSMA in Mp stacks biological activity in recipient cells.

Figure 7:

PSMA-Mp activates a switch in the tumor microenvironment that drives prostate cancer angiogenesis at early time points in PCa. This tissue switch is activated by increased secretion of pro-angiogenic factors to TME cells, leading to increased 4EBP-1-phosphorylation and then boosting the TME to produce pro-angiogenic and pro-lymph-angiogenesis secondary mediators (Figure made with Biorender.com software).