Figure 7: PSMA in Mp stacks biological activity in recipient cells.
PSMA-Mp activates a switch in the tumor microenvironment that drives prostate cancer angiogenesis at early time points in PCa. This tissue switch is activated by increased secretion of pro-angiogenic factors to TME cells, leading to increased 4EBP-1-phosphorylation and then boosting the TME to produce pro-angiogenic and pro-lymph-angiogenesis secondary mediators (Figure made with Biorender.com software).