Table 3. . HCRU costs incurred during exacerbation episodes by commercial and Medicare patients grouped according to last recorded MG exacerbation during follow-up†.
| First exacerbation | Second exacerbation | Third exacerbation | ||||
|---|---|---|---|---|---|---|
| Repeat exacerbation | No repeat exacerbation | Repeat exacerbation | No repeat exacerbation | Repeat exacerbation | No repeat exacerbation | |
| Commercial patients, n | 801 | 905 | 504 | 297 | 367 | 137 |
| Total all-cause costs ($), mean (SD) | 45,164 (105,736) | 44,700 (120,855) | 33,425 (49,133) | 41,907 (100,668) | 27,749 (46,562) | 54,217 (94,295) |
| Total MG-related costs ($), mean (SD) | 43,043 (103,223) | 43,140 (120,249) | 31,787 (47,438) | 39,304 (100,271) | 26,078 (45,431) | 51,120 (87,818) |
| MG-related ED cost ($), mean (SD) | 8361 (29,928) | 12,420 (106,377) | 6472 (27,367) | 6829 (20,927) | 3778 (20,160) | 10,995 (44,729) |
| MG-related ICU cost ($), mean (SD) | 3634 (18,189) | 4155 (26,886) | 1825 (14,716) | 1484 (5202) | 1729 (7606) | 3458 (17,289) |
| MG-related IP cost ($), mean (SD) | 24,280 (96,530) | 26,732 (57,595) | 12,510 (33,359) | 20,622 (38,298) | 9354 (33,775) | 22,045 (42,475) |
| MG-related OP cost ($), mean (SD) | 9470 (23,673) | 3822 (11,503) | 11,507 (22,738) | 11,287 (91,920) | 11,095 (23,730) | 17,328 (54,945) |
| Medicare patients, n | 541 | 728 | 282 | 259 | 172 | 110 |
| Total all-cause costs ($), mean (SD) | 32,625 (50,928) | 39,743 (74,427) | 30,127 (57,423) | 33,265 (45,754) | 21,024 (27,787) | 52,029 (177,860) |
| Total-MG-related costs ($), mean (SD) | 31,625 (50,283) | 38,529 (74,154) | 29,274 (57,076) | 31,378 (43,511) | 19,903 (26,362) | 49,967 (173,860) |
| MG-related ED cost ($), mean (SD) | 6033 (21,063) | 5652 (17,010) | 3493 (15,128) | 4335 (11741) | 2245 (9488) | 9318 (35,104) |
| MG-related ICU cost ($), mean (SD) | 3361 (19,104) | 2358 (12,024) | 811 (4674) | 1537 (7060) | 821 (6380) | 854 (2285) |
| MG-related IP cost ($), mean (SD) | 21,082 (48,296) | 30,925 (73,667) | 16,579 (49,513) | 22,221 (39,096) | 5591 (16,696) | 35,656 (167,388) |
| MG-related OP costs ($), mean (SD) | 3805 (11,068) | 1723 (9843) | 7976 (22,467) | 4229 (20,777) | 10,366 (20,179) | 3725 (10,219) |
†
Patients who experienced ≥1 exacerbation during follow-up were grouped according to whether they experienced a subsequent exacerbation – ‘repeat exacerbation’ or whether they did not experience a subsequent exacerbation – ‘no repeat exacerbation’. The ‘repeat’ or ‘no repeat’ categorization was made for each of the first, second and third exacerbation.
ED: Emergency department; HCRU: Healthcare resource utilization; ICU: Intensive care unit; IP: Inpatient; MG: Myasthenia gravis; OP: Outpatient; SD: Standard deviation.