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. Author manuscript; available in PMC: 2024 Feb 5.
Published in final edited form as: Cell Rep. 2023 Sep 26;42(10):113175. doi: 10.1016/j.celrep.2023.113175

Figure 1. Atomic force microscopy measurements of μ-compression moduli in GBM xenografts (HK408) explanted from the mouse brain revealed elevated stiffness in tumor tissue compared to non-tumor tissue.

Figure 1.

(A) Kaplan-Meier survival curve of mice with patient-derived GBM xenografts.

(B) Representative tissue sections, collected at the time of euthanasia, of xenografted tumors and their position on the Kaplan-Meier survival curve. Tumor region is marked with dashed white lines. Scale bar, 1 mm.

(C) Median atomic force microscopy (AFM) measurements in explanted tissue slices where “C” indicates tumor core, “E” indicates tumor edge “E,” and “PT” indicates peritumoral brain tissue (n = 5 for each region; data shown are median ± 95% confidence interval, Kruskal-Wallis multiple comparison test, ****p < 0.0001).

(D) Histogram of regional AFM measurements of μ-compressive modulus, normalized within each tissue section to measurements of the “PT” region (n = 5 mice, Kruskal-Wallis multiple comparison test, p < 0.0001).