Table I. New genome projects (completed or in progress) and Gates Foundation-funded orphan drug and vaccine initiatives for developing countries.
Infectious disease | Genome project | Genomics funding | Drug | Vaccine initiative | Amount ($ million) |
---|---|---|---|---|---|
African trypanosomiasis | TIGR/Sanger | NIAID/Beowolf | Drug development | University of North Carolina | 15 |
Children’s Vaccine Fund | GAVI (Geneva) | 750 | |||
Cholera/Typhoid/Shigella | TIGR/Sanger/University of Wisconsin | NIAID/Wellcome | International Vaccine Institute (Seoul) | 40 | |
HIV/AIDS | International AIDS Vaccine Initiative | 125 | |||
Hookworm | Washington University/Sanger | NIAID/Beowolf | Hookworm Vaccine | Sabin Institute | 18 |
Leishmaniasis | SBRI/Sanger | Beowolf/EC/NIAID | Leishmaniasis Vaccine | IDRI | 15 |
Lymphatic filariasis | Sanger/Smith College | Beowolf/NIAID | Drug control | World Bank | 20 |
Malaria | TIGR/NMRI/Sanger | NIAID/BWF/Wellcome | Malaria Vaccine Initiative | PATH | 50 |
SAIC | Malaria Vaccine | NIH | 40 | ||
London School of Hygiene & Tropical Medicine | 40 | ||||
Measles | Improved vaccine | Johns Hopkins University/UMD | 20 | ||
Meningococcal meningitis | TIGR/Sanger | Chiron/Wellcome | Meningitis Vaccine | PATH–WHO | 70 |
Trachoma | TIGR | NIAID | Drug control | International Trachoma Initiative | 20 |
Tuberculosis | Sanger/TIGR | Wellcome/NIAID | TB Vaccine Initiative | Sequella | 25 |
MDR | TB | Control | Harvard | 45 | |
TB Diagnosis Initiative/TDR | WHO | 10 |
Sources: www.gatesfoundation.org, www.niaid.nih.gov, www.tigr.org, Hotez (2001).